An antisocial maverick doctor who specializes in diagnostic medicine does whatever it takes to solve puzzling cases that come his way using his crack team of doctors and his wits.
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Episode 24: Both Sides Now
House takes on a case of a patient with two different personalities as a result of having the left and right part of the brain operating independently.
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Episode 23: Under My Skin
While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.
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Episode 22: House Divided
A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House's insomnia proves a curse... and a blessing.
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Episode 21: Saviors
Cameron and Chase are going on vacation when they meet an enviromentalist who collapses in the middle of a protest. They postpone their vacation and ask House to take on the case.
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Episode 20: Simple Explanation
The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband.
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Episode 19: Locked In
House is injured in a motorcycle accident in Middletown and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what's wrong with him, Wilson tries to find out why House was in...
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Episode 18: Here Kitty
A nursing-home worker (Judy Greer) is alarmed when the home's cat curls up next to her. It seems that this cat cuddles up only to people who are going to die soon. Meanwhile, a financially strapped Taub reconnects with an entrepreneurial friend from high
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Episode 17: The Social Contract
House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe inhibition, which causes him to speak his mind having no control over what he says and making him just like House.
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Episode 16: The Softer Side
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.
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Episode 15: Unfaithful
House struggles with his own beliefs as he takes on a case of priest with a disturbing past who runs a shelter for homeless people and sees a vision of Jesus.
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Episode 14: The Greater Good
A former cancer researcher collapses in the middle of a cooking class, and the team are forced to reevaluate their own lives when they learn she gave up a promising career to seek personal happiness. Meanwhile, Thirteen suffers adverse reactions from the ...
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Episode 13: Big Baby
The team take on the case of a Special Education teacher who spits up blood and collapses in the middle of class. Meanwhile, Cameron finds herself taking on some of Cuddy's duties, including dealing with House, and Foreman has to make a decision concernin...
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Episode 12: Painless
Thirteen receives treatment by Foreman while taking part in his clinical trial on Huntington's Disease.
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Episode 11: Joy to the World
House and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug trials, House gives a patient a gift, the staff wonder who gave House a specical...
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Episode 10: Let Them Eat Cake
The team take on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington's Disease drug trials and Thirteen signs on as a subject, Cuddy is forced to move into House's office, and Kutne
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Episode 09: Last Resort
A man takes over Cuddy's office and holds House, Thirteen, and several patients hostage. His demand? A diagnosis. The man forces Thirteen to act as a guinea pig for his treatments and House has to end the standoff before a SWAT team opens fire.
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Episode 08: Emancipation
While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patient takes a turn for the worse, he's forced to question whether he can...
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Episode 07: The Itch
The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relationship issues.
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Episode 06: Joy
An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man's daughter grows ill as well, the team must provide a diagnosis before bot...
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Episode 05: Lucky Thirteen
Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him diagnose her condition. Meanwhile, House continues to pay Lucas to spy on Wils...
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Episode 04: Birthmarks
While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.
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Episode 03: Adverse Events
A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.
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Episode 02: Not Cancer
An organ donor's organs are responsible for the deaths of several patients, and the team work to save the last two recipients.
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Episode 01: Dying Changes Everything
In the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while helping treat an executive assistant with a similar personality to her own...
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